منابع مشابه
Regulation of Protein Degradation.
INTRODUCTION The intracellular level of a protein is dependent on both its rate of synthesis and its rate of degradation. Thus, differential regulation of protein stability represents a potential mechanism for modulating gene expression. lncreasing evidence suggests that protein degradation is indeed a regulatory mechanism in vivo. Dramatic differences in the in vivo stability of different prot...
متن کاملRegulation of protein degradation in skeletal muscle.
Protein balance in rat muscles incubated in vitro is influenced by the supply of insulin, leucine and various hormones at physiological concentrations (0.1-0.5 mM) (Goldberg & Chang, 1978; Goldberg et al., 1980). Leucine, but no other amino acid, stimulates protein synthesis and inhibits protein breakdown in this tissue. Metabolism of leucine is necessary for its inhibitory effect on proteolysi...
متن کاملMicrotubule-dependent regulation of mitotic protein degradation.
Accurate cell division depends on tightly regulated ubiquitylation events catalyzed by the anaphase-promoting complex (APC/C). Among its many substrates, the APC/C triggers the degradation of proteins that stabilize the mitotic spindle, and loss or accumulation of such spindle assembly factors can result in aneuploidy and cancer. Although critical for cell division, it has remained poorly under...
متن کاملDiscovery of cellular regulation by protein degradation.
I was born and educated in Russia, and was 30 at the time of emigration to the U.S., in 1977. Over the last three decades, studies by my laboratory encompassed several fields. While the title of this article is about our main contribution to date, I describe other significant advances as well, in addition to new biochemical and genetic methods introduced by the lab. A condensed summary, below, ...
متن کاملRuminal Protein Degradation and Estimation of Rumen Microbial Protein Production
Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 1995
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.7.7.845